Endocrine Abstracts

Given the increasing incidence in psychiatric pathology, adverse reactions of psychotropic medications, especially the metabolic and endocrine side effects, are encountered more frequently in clinical practice. We present the cases of two female patients with psychiatric pathology, in whom the specific treatment was accompanied by significant endocrine adverse reactions, making the tumoural differential diagnosis very difficult. The first case is of a patient aged 61 years, kn...

Introduction: We should consider testing for primary aldosteronism in the presence of hypertension and hypokalaemia, resistant hypertension, onset of hypertension at a young age (<20 year), severe hypertension and whenever considering secondary hypertension.Case report: We presented the case of a 38 years old woman who was admitted in the National Institute of Endocrinology C.I. Parhon Bucharest for the evaluation of high blood pressure. She has high...

Catecholamines can cause hypertension by increasing heart rate and cardiac output or by peripheral vasoconstriction.Aim of study: The value of plasma and urinary metanephrines and normetanephrines does not correlate with blood pressure in pheochromocytomas.Material and methods: The lot of study consist of 35 patients with isolated pheochromocytomas diagnosed between 1985 and 2005 in National Institute of Endocrinology C.I.Parhon Bu...

We presented the case of a 20-year-old woman which has presented for endocrinologic evaluation after right adrenalectomy for pheochromocytoma. From her heredocolateral antecedents, we retain her grandmother and sister of her father with sudden cardiac death at early age. At this presentation, she had normal plasma and urinary MN and NMN. Plasma Cg A and Serotonin are normal and the CT exam showed right adrenalectomy and right renal microlitiasis. Genetic analysis showed mutati...

Objectives: Endothelial dysfunction has been described as a predictor of cardiovascular complications. Most important cause for early mortality in acromegaly is cardiovascular involvement, cut-off nadir GH <2.5 ng/ml predicting longer survival The aim of our study was to determine the correlations between endothelial dysfunction and GH oversecretion, associated or not with other cardiovascular risk factors.Design and method: Cross-sectional study inc...

Foreign bodies represent a rare cause of granulomatous mastitis. In the last three years we diagnosed three women with granulomatous mastitis consecutive to exposure at building materials containing glass fibers. All of them were young (21–34 years), with regular menses, without any pathological histories and were admitted to our hospital for bilateral galactorrhea spontaneous in one case and by squeezing the nipple in the other two cases. Clinical and ultrasonographic ev...

Objective: The best biochemical strategy to follow in pheochromocytoma clinical diagnosis.Patients and methods: We selected two groups of patients: 24 pheochromocytomas (further diagnosed by CT): 20 women and 4 men aged 20–68 years and a normotensive group: 100 subjects without endocrine disfunction: 83 women and 17 men aged 19–70 years. In both groups we tested five parameters: plasma normetanephrines/metanephrines (NMNp/MNp); urine normetanep...

Objective: To introduce the best biochemical strategy for carcinoid syndrome diagnosis.Patients and methods: We selected two groups of patients: one group of 75 patients suspected of carcinoid syndrome: 57 women aged between 19 and 78 years and 18 men aged 17–81 years and a 80 healthy subjects group without endocrine disfunction: 56 women aged between 27 and 78 years and 24 men aged 17–81 years. We established median values for all parameters i...

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

Objectives: Metabolic syndrome, especially obesity and diabetes are associated and responsible for a depressive psychological status. Meanwhile, antidepressors are responsible for metabolic disturbances, such as insulin resistance. The study aims to determine predictive factors of response to antidepressant pharmacotherapy in patients with metabolic syndrome.Materials and methods: A retrospective study conducted in Institute Parhon’s Department for ...